Research program focuses on understanding protein structures. He is interested in characterizing their shapes, and uses this information to improve our understanding of their stability (ProShape). He is also interested in characterizing the subset of sequence space compatible with a protein structure: this is an indirect approach to understanding protein sequence evolution (ProDesign) . In parallel, he is involved in the development of new algorithms for predicting the structure of a protein, based on its sequence (ProModel). Dr. Koehl will also have a research appointment with the Genome Center.