{"id":17,"date":"2013-02-26T20:32:40","date_gmt":"2013-02-26T20:32:40","guid":{"rendered":"http:\/\/faculty.engineering.ucdavis.edu\/template\/?page_id=17"},"modified":"2026-09-21T00:15:42","modified_gmt":"2026-09-21T00:15:42","slug":"publications","status":"publish","type":"page","link":"https:\/\/faculty.engineering.ucdavis.edu\/sivasankar\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
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  1. Davis, C. M. O., Pagay, S. S., Khatiwada, P., Wu, Y., Sivasankar, S.,*, (2026<\/strong>)\u00a0 A dimerization-activated proximity labeling system for direct characterization of cadherin cis interactions.,\u00a0 bioRxiv<\/strong><\/em>, 2025-11<\/a><\/span><\/li>\n
  2. Xu, S., Mudiyanselage, N.H., Sivasankar, S.*, (2025<\/strong>)\u00a0 P-cadherin and desmoglein-2 interact as strand-swap dimers and facilitate desmosome assembly.,\u00a0 bioRxiv<\/strong><\/em>, 2025-09<\/a><\/span><\/li>\n
  3. Dong, Y., Elgerbi, A., Xie, B., Han, Y., Kwiatkowski, A.V., Choy, J.S., Sivasankar, S.*, (2025<\/strong>)\u00a0 Actomyosin forces trigger a conformational change in desmoplakin within desmosomes.,\u00a0 Nature Communications<\/strong><\/em>, 16, Article number: 9052 <\/a><\/span><\/li>\n
  4. Davis, C.M.O., Sivasankar, S.*, (2025<\/strong>)\u00a0 On-Demand Proximity Labeling Using Light-Activated BioID.,\u00a0 Proximity-Dependent Protein Biotinylation: Methods and Protocols<\/strong><\/em>, Springer US, 215-230 <\/a>\u00a0<\/span><\/li>\n
  5. Xie, B.^, Xu, S.^, Sivasankar, S.*, (2025<\/strong>)\u00a0 Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody.,\u00a0 Nature Communications<\/strong><\/em>, 16, Article number: 1157 <\/a>\u00a0<\/span><\/li>\n
  6. Waschke, J., Amagai, M., Becker, C., Delmar, M., Duru, F., Garrod, D.R., Gerull, B., Green, K.J., Hertl, M., Kowalczyk, A.P., Niessen, C.M., Nusrat, A., Schinner, C., Schlegel, N., Sivasankar, S., Vielmuth, F., Spindler, V., (2025<\/strong>)\u00a0 Meeting report \u2013 Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases.,\u00a0 Journal of Cell Science<\/strong><\/em>, 138 (2): jcs263796. <\/a><\/span><\/li>\n
  7. Xie, B., Xu, S., Schecterson, L., Gumbiner, B.M., Sivasankar, S.*, (2024<\/strong>)\u00a0 Strengthening E-cadherin adhesion via antibody mediated binding stabilization.,\u00a0 Structure<\/strong><\/em>, 32 (2), 217-227. e3. <\/a>\u00a0<\/span><\/li>\n
  8. Shafraz, O.^, Davis, C.M.O.^, Sivasankar, S.*, (2023<\/strong>)\u00a0 Light Activated BioID (LAB): an optically activated proximity labeling system to study protein-protein interactions.,\u00a0 Journal of Cell Science<\/strong><\/em>, 136 (19): jcs261430<\/a><\/span><\/li>\n
  9. Shome, S., Jia, K., Sivasankar, S., Jernigan, R.L., (2023<\/strong>)\u00a0 Characterizing interactions in E-cadherin assemblages; Biophysical Journal<\/strong><\/em>, 22 (15): 3069-3077<\/a>\u00a0<\/span><\/li>\n
  10. Sivasankar, S.*, Xie, B, (2023<\/strong>)\u00a0 Engineering the interactions of classical cadherin cell-cell adhesion proteins; Journal of Immunology<\/strong><\/em>, 211 (3): 343\u2013349.<\/a><\/span><\/li>\n
  11. Priest, A., Sivasankar, S.*, (2023<\/strong>)\u00a0 Characterizing the biophysical properties of adhesive proteins in live cells using single molecule Atomic Force Microscopy,\u00a0 Methods in Molecular Biology, Mechanobiology: Methods and Protocols<\/strong><\/em>, 63-77<\/a><\/span><\/li>\n
  12. Xie, B., Maker, A., Priest, A., Dranow, D.M., Phan, J.N., Edwards, T.E., Staker, B., Myler, P.J., Gumbiner, B.M., Sivasankar, S.*, (2022<\/strong>)\u00a0 Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody,\u00a0 Proceedings of the National Academy of Sciences of the United States of America<\/strong><\/em>, 119 (32) e2204473119<\/a><\/span><\/li>\n
  13. Priest, A.^, Koirala, R.^, Sivasankar, S.*, (2022<\/strong>)\u00a0 Cadherins can dimerize via asymmetric interactions,\u00a0 FEBS Letters<\/strong><\/em>, 596, 1639\u20131646<\/a><\/span>
    \nSelected as the journal cover image<\/strong><\/span>
    \n    \"Selected<\/a><\/span>\u00a0<\/span><\/li>\n
  14. Koirala, R.^, Priest, A.^, Yen, C.F., Cheah, J., Pannekoek, W.J., Gloerich, M., Yamada, S., Sivasankar, S.*, (2021<\/strong>)\u00a0 Inside-out regulation of E-cadherin conformation and adhesion,\u00a0 Proceedings of the National Academy of Sciences of the United States of America<\/strong><\/em>, 118 (30) e2104090118<\/a><\/span>
    \n    \"Access<\/a><\/span>\u00a0<\/span><\/li>\n
  15. Schmidt, P., Lajoie, J., Sivasankar, S.*, (2021<\/strong>)\u00a0 Robust scan synchronized force-fluorescence imaging,\u00a0 Ultramicroscopy<\/strong><\/em>, 221, 113165<\/a><\/span>\u00a0<\/span><\/li>\n
  16. Shafraz, O., Xie, B., Yamada, S., Sivasankar, S.*, (2020<\/strong>)\u00a0 Mapping transmembrane binding partners for E-cadherin ectodomains,\u00a0 Proceedings of the National Academy of Sciences of the United States of America<\/strong><\/em>, 117 (49) 31157-31165 <\/a><\/span>\u00a0<\/span><\/li>\n
  17. Schmidt, P.D., Reichert, B.H., Lajoie, J.G., Sivasankar, S.*, (2020<\/strong>)\u00a0 Adaptive atomic force microscope,\u00a0 Proc. SPIE, Single Molecule Spectroscopy and Superresolution Imaging XIII<\/strong><\/em>, Article number: 1124604 <\/a><\/span><\/li>\n
  18. Tavakoli, M., Jazani, S., Sgouralis, I., Shafraz, O., Donaphon, B., Sivasankar, S., Levitus, M., Press\u00e9, S., (2020<\/strong>)\u00a0Re-pitching single focus confocal data analysis one photon at a time with Bayesian nonparametrics,\u00a0 Physical Review X<\/strong><\/em>, 10, Article number: 011021<\/a><\/span><\/li>\n
  19. Priest, A.V.^, Koirala, R.^, Sivasankar, S.*, (2019<\/strong>)\u00a0Single molecule studies of classical and desmosomal cadherin adhesion,\u00a0 Current Opinion in Biomedical Engineering<\/strong><\/em>, 12, pages 43-50<\/a><\/span><\/li>\n
  20. Jazani, S., Sgouralis, I., Shafraz, O., Levitus, M., Sivasankar, S., Press\u00e9, S., (2019<\/strong>) An Alternative Framework for Fluorescence Correlation Spectroscopy, Nature Communications<\/em><\/strong>, 10, Article number:3662<\/a><\/span><\/li>\n
  21. Shafraz, O.^, R\u00fcbsam, M.^, Stahley, S., Caldara, A., Kowalczyk, A., Niessen, C., Sivasankar, S.*, (2018<\/strong>) E-cadherin binds to desmoglein to facilitate desmosome assembly, eLife<\/em><\/strong>, 7, e37629.<\/a><\/span>
    \n    \"Access<\/a><\/span><\/li>\n
  22. Schmidt, P., Reichert, B., Lajoie. J., Sivasankar, S.*, (2018<\/strong>) Method for high frequency tracking and sub-nm sample stabilization in single molecule fluorescence microscopy, Scientific Reports<\/em><\/strong>, 8, 13912.<\/a><\/span><\/li>\n
  23. Yen, C.F., Sivasankar, S.*, (2018<\/strong>) Improving estimation of kinetic parameters in dynamic force spectroscopy using cluster analysis, The Journal of Chemical Physics<\/em><\/strong>, 148, 123301.<\/a><\/span><\/li>\n
  24. Yen, C.F., Sivasankar, S.*, (2017<\/strong>) Minimizing open-loop piezo actuator nonlinearity artifacts in atomic force microscope measurements, Journal of Vacuum Science & Technology B<\/em><\/strong>, 35, 053201.<\/em><\/a><\/span><\/li>\n
  25. Priest, A.V.^, Shafraz, O.^, Sivasankar, S.*, (2017<\/strong>) Biophysical basis of cadherin mediated cell-cell adhesion, Experimental Cell Research<\/em><\/strong>, 358, pp. 10-13.<\/a><\/span><\/li>\n
  26. Manibog, K.^, Yen,C.F.^, Sivasankar, S.*, (2017<\/strong>) Measuring force induced dissociation kinetics of protein complexes using single molecule atomic force microscopy, Methods in Enzymology<\/em><\/strong>, 582, 297-320.<\/a><\/span><\/li>\n
  27. Manibog, K., Sankar, K., Kim, S., Zhang, Y., Jernigan, R., Sivasankar, S.*, (2016<\/strong>) Molecular determinants of cadherin ideal bond formation: Conformation-dependent unbinding on a multidimensional landscape, Proceedings of the National Academy of Sciences of the United States of America<\/em><\/strong>, 113, no. 39, pp. E5711-E5720.<\/a><\/span><\/li>\n
  28. Yen, C.F., Harishchandra, D., Kanthasamy, A., Sivasankar, S.*, (2016<\/strong>) Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity, Science Advances<\/em><\/strong>, 2, 7, e1600014.<\/a><\/span><\/li>\n
  29. Manibog, K., Li, H., Rakshit, S., Sivasankar, S.*, (2014<\/strong>) Resolving the molecular mechanism of cadherin catch bond formation, Nature Communications<\/em><\/strong>, 5, Article number:3941.<\/a><\/span><\/li>\n
  30. Lowndes, M., Rakshit, S., Shafraz, O., Borghi, N., Harmond, R., Green, K., Sivasankar, S., Nelson, W.J., (2014<\/strong>) Distinguishing roles of different cadherins in the assembly and structural integrity of the desmosome complex, Journal of Cell Science<\/em><\/strong>,127, 2339-2350.<\/a><\/span><\/li>\n
  31. Rakshit, S., Sivasankar, S.*, (2014<\/strong>) Biomechanics of cell adhesion: How force regulates the lifetime of adhesive bonds at the single molecule level, Physical Chemistry Chemical Physics<\/em><\/strong>, 16, 2211-2223.<\/a><\/span><\/li>\n
  32. Sivasankar, S.*, (2013<\/strong>) Tuning the kinetics of cadherin adhesion, Journal of Investigative Dermatology<\/em><\/strong>, 133, 2318-2323.<\/a><\/span><\/li>\n
  33. Rakshit, S., Zhang, Y.X., Manibog, K., Shafraz, O., Sivasankar, S.*, (2012<\/strong>) Ideal, catch and slip bonds in cadherin adhesion, Proceedings of the National Academy of Sciences of the United States of America<\/em><\/strong>, 109, 18815-18820.<\/a><\/span>
    \n    \"Access<\/a><\/span><\/li>\n
  34. Li, H.^, Yen, C.F.^, Sivasankar, S.*, (2012<\/strong>) Fluorescence Axial Localization with Nanometer Accuracy and Precision, Nano Letters<\/em><\/strong>, 12, 3731-3735.<\/a><\/span>
    \n    \"Access<\/a><\/span><\/li>\n
  35. Leckband, D., Sivasankar, S., (2012<\/strong>) Cadherin recognition and adhesion, Current Opinion in Cell Biology<\/em><\/strong>, 24, 1-8.<\/a><\/span><\/li>\n
  36. Leckband, D., Sivasankar, S., (2012<\/strong>) Biophysics of cadherin adhesion, Springer: Sub-cellular Biochemistry<\/em><\/strong>, Volume: 60, Pages: 63-88.<\/a><\/span><\/li>\n
  37. Choi, C.L., Li, H., Olson, A.C.K., Jain, P.K., Sivasankar, S.*, Alivisatos, A.P.*, (2011<\/strong>) Spatially indirect emission in a luminescent nanocrystal molecule, Nano Letters<\/em><\/strong>, 11, 2358-2362.<\/a><\/span><\/li>\n
  38. Li, H., Fowler, N., Struck, C., Sivasankar, S.*, (2011<\/strong>) Flow triggered by instabilities at the contact-line of a drop containing nanoparticles, Soft Matter<\/em><\/strong>, 7, 5116-5119.<\/a><\/span><\/li>\n
  39. Rakshit, S., Sivasankar, S.*, (2011<\/strong>) Cross-linking of a charged polysaccharide using polyions as electrostatic staples, Soft Matter<\/em><\/strong>, 7, 2348-2351.<\/a><\/span><\/li>\n
  40. Choi, C.L., Koski, K.J., Sivasankar, S., Alivisatos, A.P., (2009<\/strong>) Strain-Dependent Photoluminescence Behavior of CdSe\/CdS Nanocrystals with Spherical, Linear, and Branched Topologies, Nano Letters<\/em><\/strong>, 9, 3544-3549.<\/a><\/span><\/li>\n
  41. Sivasankar, S.^*, Zhang, Y.^, Nelson,W.J., and Chu, S.*, (2009<\/strong>) Characterizing the initial encounter complex in cadherin adhesion, Structure<\/em><\/strong>, 17, 1-7.<\/a><\/span>
    \n    (Selected for an editor\u2019s choice preview)<\/em><\/a><\/strong><\/span><\/li>\n
  42. Sivasankar, S.* and Chu, S., (2009<\/strong>) Nanoparticle mediated non-fluorescent bonding of microspheres to atomic force microscope cantilevers and imaging fluorescence from bonded cantilevers with single molecule sensitivity, Nano Letters<\/em><\/strong>, 9, 2120-2124.<\/a><\/span><\/li>\n
  43. Zhang, Y.^, Sivasankar, S.^*, Nelson,W.J., and Chu, S.*, (2009<\/strong>) Resolving cadherin interactions and binding cooperativity at the single molecule level, Proceedings of the National Academy of Sciences of the United States of America<\/em><\/strong>, 106, 109-114.<\/a><\/span><\/li>\n
  44. Sivasankar, S., and Chu, S., (2007<\/strong>) Optical bonding using silica nanoparticle sol-gel chemistry, Nano Letters<\/em><\/strong>, 7, 3031-3034.<\/a><\/span><\/li>\n
  45. Sivasankar, S., Gumbiner, B., and Leckband, D., (2001<\/strong>) Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains, Biophysical Journal<\/em><\/strong>, 80, 1758-1768.<\/a><\/span><\/li>\n
  46. Leckband, D., and Sivasankar, S., (2000<\/strong>) Mechanism of homophilic cadherin adhesion, Current Opinion in Cell Biology<\/em><\/strong>, 12, 587-592.<\/a><\/span><\/li>\n
  47. Leckband, D., and Sivasankar, S., (1999<\/strong>) Forces controlling protein interactions: theory and experiment, Colloids and Surfaces B: Biointerfaces<\/em><\/strong>, 14, 83-97.<\/a><\/span><\/li>\n
  48. Sivasankar, S., Brieher, W., Lavrik, N., Gumbiner, B., and Leckband, D., (1999<\/strong>) Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains, Proceedings of the National Academy of Sciences of the United States of America<\/em><\/strong>, 96, 11820-11824.<\/a><\/span><\/li>\n
  49. Sivasankar, S., Subramaniam, S., and Leckband, D., (1998<\/strong>) Direct molecular level measurements of the electrostatic properties of a protein surface, Proceedings of the National Academy of Sciences of the United States of America<\/em><\/strong>, 95, 12961-12966.<\/a><\/span><\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

    Davis, C. M. O., Pagay, S. S., Khatiwada, P., Wu, Y., Sivasankar, S.,*, (2026)\u00a0 A dimerization-activated proximity labeling system for direct characterization of cadherin cis interactions.,\u00a0 bioRxiv, 2025-11 Xu, S., Mudiyanselage, N.H., Sivasankar, S.*, (2025)\u00a0 P-cadherin and desmoglein-2 interact as strand-swap dimers and facilitate desmosome assembly.,\u00a0 bioRxiv, 2025-09 Dong, Y., \u2026 Continue reading → <\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"inline_featured_image":false,"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/faculty.engineering.ucdavis.edu\/sivasankar\/wp-json\/wp\/v2\/pages\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/faculty.engineering.ucdavis.edu\/sivasankar\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/faculty.engineering.ucdavis.edu\/sivasankar\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/faculty.engineering.ucdavis.edu\/sivasankar\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.engineering.ucdavis.edu\/sivasankar\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":10,"href":"https:\/\/faculty.engineering.ucdavis.edu\/sivasankar\/wp-json\/wp\/v2\/pages\/17\/revisions"}],"predecessor-version":[{"id":271,"href":"https:\/\/faculty.engineering.ucdavis.edu\/sivasankar\/wp-json\/wp\/v2\/pages\/17\/revisions\/271"}],"wp:attachment":[{"href":"https:\/\/faculty.engineering.ucdavis.edu\/sivasankar\/wp-json\/wp\/v2\/media?parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}