{"id":20,"date":"2013-02-26T20:37:53","date_gmt":"2013-02-26T20:37:53","guid":{"rendered":"http:\/\/faculty.engineering.ucdavis.edu\/template\/?page_id=20"},"modified":"2013-06-28T20:01:00","modified_gmt":"2013-06-28T20:01:00","slug":"research","status":"publish","type":"page","link":"https:\/\/faculty.engineering.ucdavis.edu\/sutcliffe\/research\/","title":{"rendered":"Research Interests"},"content":{"rendered":"<p><em>Development of Targeted Molecular Imaging Agents<\/em><em><\/em><\/p>\n<p>Dr. Sutcliffe\u2019s research involves the design, synthesis and\u00a0<em>in vivo<\/em>\u00a0evaluation of targeted molecular imaging agents with a focus on PET. Her group has developed rapid radiolabeling technologies using both solid-phase and solution-phase chemistries to incorporate the short half-life PET radionuclide 18F into peptides. Peptide based radiopharmaceuticals are gaining extensive attention as targeted molecular imaging agents. It is therefore important that technologies are developed that allow these agents to be synthesized rapidly and screened both<em>\u00a0in vitro<\/em>\u00a0and\u00a0<em>in vivo<\/em>\u00a0to assess their efficacy. Her group applies radiolabeled peptides to target cell surface receptors\u00a0<em>in vivo<\/em>\u00a0using small animal imaging. Major cell surface receptors of interest include the integrin receptors alpha(v)beta(3) and alpha(v)beta(6). Integrins are cell surface glycoproteins involved in cell-cell and cell- extracellular matrix interactions. Their over expression has been associated with many diseases including cancer. In particular alpha(v)beta(6) is expressed at low or undetectable levels on normal tissue and is upregulated on many cancers including oral squamous cell carcinoma, breast cancer, pancreatic cancer and has recently been identified as a marker of prognosis in colon and lung cancer.\u00a0<em>In vivo<\/em>\u00a0imaging of this receptor could therefore have a significant impact on patient diagnosis, care and management. Dr Sutcliffe\u2019s group uses two approaches to develop targeted molecular imaging agents to image cell surface receptors A \u201crational approach\u201d based on known binding structures and a \u201crandom approach\u201d using the one-bead-one-compound molecular library methodology. Peptides are synthesized using standard Fmoc chemistries, screened\u00a0<em>in vitro<\/em>\u00a0for affinity and selectivity and subsequently radiolabeled and screened\u00a0<em>in vivo<\/em>using small animal imaging.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Development of Targeted Molecular Imaging Agents Dr. Sutcliffe\u2019s research involves the design, synthesis and\u00a0in vivo\u00a0evaluation of targeted molecular imaging agents with a focus on PET. Her group has developed rapid radiolabeling technologies using both solid-phase and solution-phase chemistries to incorporate the short half-life PET radionuclide 18F into peptides. Peptide based \u2026 <a class=\"continue-reading-link\" href=\"https:\/\/faculty.engineering.ucdavis.edu\/sutcliffe\/research\/\"> Continue reading <span class=\"meta-nav\">&rarr; <\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-twocolumns-left.php","meta":{"inline_featured_image":false,"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-20","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/faculty.engineering.ucdavis.edu\/sutcliffe\/wp-json\/wp\/v2\/pages\/20","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/faculty.engineering.ucdavis.edu\/sutcliffe\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/faculty.engineering.ucdavis.edu\/sutcliffe\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/faculty.engineering.ucdavis.edu\/sutcliffe\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/faculty.engineering.ucdavis.edu\/sutcliffe\/wp-json\/wp\/v2\/comments?post=20"}],"version-history":[{"count":21,"href":"https:\/\/faculty.engineering.ucdavis.edu\/sutcliffe\/wp-json\/wp\/v2\/pages\/20\/revisions"}],"predecessor-version":[{"id":225,"href":"https:\/\/faculty.engineering.ucdavis.edu\/sutcliffe\/wp-json\/wp\/v2\/pages\/20\/revisions\/225"}],"wp:attachment":[{"href":"https:\/\/faculty.engineering.ucdavis.edu\/sutcliffe\/wp-json\/wp\/v2\/media?parent=20"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}